Long-term Effects of LSD
LSD, or d-lysergic acid diethylamide, belongs to a class of drugs called hallucinogens. Also referred to as “acid,” LSD can be taken orally in tablets, capsules, as a liquid or on paper that’s been saturated with the drug. An LSD “trip” or episode may last up to 12 hours or more.1
In cases of mild to moderate intake, the long-term effects of LSD more frequently involve the brain and psyche rather than the body. Frequent users may experience episodes of psychosis – with severely altered perceptions – for years after they’ve stopped taking the drug.
Another common effect of long-term LSD use is recurring “flashbacks.” The condition of having LSD flashbacks is also more formally called “hallucinogen persisting perception disorder” (HPPD). The psychotic disturbances associated with HPPD may last for months or years, and you may not be able to reverse the effects of HPPD simply by quitting this drug.
Long-term Effects of LSD on the Body
Although LSD typically produces more pronounced effects in the brain over other types of bodily effects, signs of stimulation to the body’s sympathetic (or “fight-or-flight”) nervous system can sometimes result from immediate LSD use.
Long-term LSD use may increase the chance that you may choose to take large doses of LSD at some point. Large LSD doses of more than 400 mcg, however, can result in life-threatening toxicity that can manifest as:
- Hyperthermia, or overheating.
- Cardiovascular collapse, or sudden heart failure.
- Death or severe injury due to impaired judgement while intoxicated.2
Long-term Effects of LSD on the Brain
According to the Cleveland Clinic, the exact effect of LSD on the brain remains unknown. But the drug is believed to affect your brain’s response to serotonin – a neurotransmitter that involves your emotions, moods and perceptions.3
While immediate LSD use causes a variety of disorienting, distorted and emotional effects, the longer-term effects of LSD abuse on the brain include:
- Persistent psychosis – otherwise described as a state of disassociation from the real world.
- Hallucinations – even after you’ve stopped taking the drug.
Some users report having mind-expanding, mystical experiences while they’re under the influence of LSD. However, because it’s impossible to control the type of experiences you’ll have, the length of your experience or your reactions to the drug – you cannot predict if you are likely to have terrifying hallucinations or pleasant ones. Even worse, these episodes may continue after you’ve stopped using LSD, interfering with your social and professional life and putting you at risk of anxiety, depression and suicide.
“Psychosis” is defined as a condition of dissociation from the real world.4 It is characterized by:
- Hallucinations – or perceiving things that aren’t actually there.
- Delusions – or false beliefs.
People who suffer from schizophrenia, schizoaffective disorder, borderline personality disorder and other serious mental illnesses or personality disorders may also experience psychotic episodes similar to those with a history of long-term LSD use.
Even after quitting LSD, the drug-induced psychosis that may continue to persist can include:
- Radically disorganized thought patterns.
- Distortions of perceived reality.
- Dramatic mood swings.
Not everyone who uses hallucinogenic drugs experiences persistent psychosis. But many people do.
Whether these episodes occur regularly or happen only occasionally, they can be terrifying and profoundly disturbing. Persistent psychosis can make it difficult to hold down a job, maintain a normal social life and form lasting personal relationships. During a psychotic episode, you may suffer a serious or fatal injury if your delusional experiences drive you to take life-threatening risks.
Flashbacks vs. HPPD
LSD flashbacks are often the subject of jokes in the media. Psychedelic drugs were widely used in the 1960s to achieve an expanded state of consciousness, and some psychiatrists even prescribed LSD to their patients on a therapeutic or experimental basis.
Today’s references to flashbacks frequently poke fun at these visionary explorations. But while some flashbacks may be amusing, colorful and even pleasant – hallucinogen persisting perception disorder (HPPD) can be a dangerous and frightening condition. While flashbacks are usually infrequent, reversible and harmless – episodes of HPPD can be:
- A long-term, chronic side effect of LSD use.
- Extremely disturbing.
- Recurrent, reappearing over and over again.
- Accompanied by dysphoria, or a sense of depression and malaise.
- Irreversible – despite avoiding hallucinogenic drugs.
Treatment for HPPD
There is no known cure for HPPD, but a number of medications have been used to manage HPPD symptoms. The following medications have shown varying levels of success in managing HPPD symptoms:
- Clonazepam. This drug is used for treating anxiety disorders and seizures.
- SSRIs (selective serotonin reuptake inhibitors). These drugs are antidepressants that increase the amount of serotonin available in the body.
- Atypical antipsychotics (risperidone, olanzapine). These drugs are typically used to treat schizophrenia, irritability from autism and bipolar disorder.
- Clonidine. Clonidine is often used for treating high blood pressure, cancer pain and ADHD.
- Naltrexone. This drug blocks or minimizes opioids – substances that act on the nervous system similarly to morphine – and is usually used to treat alcohol and opioid dependence.
Others have suggested an alternative possible HPPD treatment using lamotrigine – a drug that stabilizes the mood stabilizer and anti-epileptic mediation.5
Individual counseling and group therapy may also be of some help to you for learning how to deal with HPPD episodes and lead a healthier, happier life.
Risk of Tolerance
LSD isn’t considered to be a physically addictive drug. And in general, you won’t experience physical withdrawal symptoms when you stop taking LSD. But the development of physical tolerance to LSD, however, is possible.
Developing more tolerance means that you’ll need to take larger doses of the drug to achieve the same hallucinogenic effects. By taking LSD, you may also build up a tolerance to other hallucinogenic drugs, such as mescaline. Tolerance usually decreases within a few days after you stop taking LSD.
Although LSD may not produce physical withdrawal symptoms, you may become psychologically dependent on hallucinogenic drugs if you take them on a regular basis. Some long-term users experience anxiety, depression or irritability if they don’t have access to LSD or other hallucinogens. The long-term physical side effects of LSD use are still being investigated.
How Prevalent Is LSD Use?
If you associate LSD use with the psychedelic ’60s, you may be surprised to learn that the drug is alive and well today, especially among the younger generation. What percentage of Americans have used LSD over the course of their whole lifetime?
According to the National Survey on Drug Use and Health, the 2014 lifetime prevalence rates among Americans are as follows:
- Age 12 and up: 9.4%
- Ages 12-17: 1.2%
- Ages 18-25: 7%
- Ages 26 and up: 10.9%6
2013 estimates for first-time LSD use in the U.S. are as follows:
- Roughly 480,000 people ages 12 and over started using LSD for the first time in the past year. This estimate is similar to – if not higher than – those of the 10 previous years.
- The average age of first hallucinogen use among Americans ages 12-49 was 19.9 years.7
A Brief History of LSD
LSD is a synthetic drug that was first produced in 1938 by Swiss scientist Albert Hoffman, who was investigating the medical uses of a fungus that grows on various types of grass.
After accidentally absorbing a small amount of the drug through his fingertips, Hoffman experienced an intense and fantasy-like distortion of his sensory perceptions – which he explained as entering a different reality, altogether. If you’ve ever experienced the psychological effects of LSD, you might well agree with his description about the LSD experience.
Recreational LSD Use: Why Should You Be Concerned?
Experimenting with LSD and other drugs is often considered to be a rite of passage among teenagers and young adults. Older adults may use LSD occasionally to experience its hallucinatory effects, to enhance their sexual encounters, to achieve a quasi-religious state of exaltation or to escape their own reality. But the unpredictable effects of LSD make the drug dangerous to anyone who takes it – even on a recreational basis. The long-term effects of LSD use on the brain, body and psyche are still not comprehensively researched.
Get the Help You Need
If you’re concerned about the effects of hallucinogenic drugs such as LSD, call our toll-free number at the top of the page to speak with a caring recovery advisor who will be happy to discuss with you further the options available for your particular situation. While LSD may not be as addictive as heroin, alcohol or cocaine – using the drug can have devastating effects on your mental and physical health.
Treatment for LSD use can occur one of a few different ways:
- Luxury and executive treatment programs provide residential drug treatment with the extra benefit of luxurious amenities to make your stay more comfortable. As a result, these programs tend to cost more than traditional treatment.
- Executive programs also specifically tailor their treatment program to allow busy professionals to remain actively involved in their work throughout their treatment.
- Traditional treatment offers lower-cost drug treatment in both inpatient and outpatient settings.
Not sure which treatment type would be best for your situation? If you’d like to learn more and get help in better understanding your options, call our number at the top of the page and get the support you need to start a new, drug-free life.
- Kranzler, H. R., Ciraulo, D. A. (Eds.). (2005). Clinical Manual of Addiction Psychopharmacology. Washington, D.C.: American Psychiatric Publishing, Inc.
- Klock, J. D., Boerner, U., Becker, C. E. (1974). Coma, hyperthermia and bleeding associated with massive LSD overdose. A report of eight cases. West J Med, 120(3), 183.
- Hallucinogens – LSD, Peyote, Psilocybin and PCP. Cleveland Clinic.
- Psychosis. Pubmed Health.
- Hallucinogen-persisting perception disorder. (2012). Ther Adv Psychopharmacol, 2(5), 199-205.
- Hallucinogens. National Institute on Drug Abuse.
- Substance Abuse and Mental Health Services Administration. (2014). Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings. NSDUH Series H-48, HHS Publication No. (SMA) 14-4863. Rockville, MD: Substance Abuse and Mental Health Services Administration.